Right ventricular myocardial work characterization in patients with pulmonary hypertension and association with pulmonary hypertension severity

Abstract Funding Acknowledgements Type of funding sources: None. Background Right ventricular myocardial work (RVMW) assessed by transthoracic echocardiography allows to study and analyze the right (RV) function non-invasively, using RV pressure-strain loops. The association between these novel indexes RVMW invasive hemodynamic parameters has not yet been extensively studied, namely in precapillary pulmonary hypertension (PH) population. Objectives To evaluate relationship severity PH through indices heart catheterization (RHC) a cohort patients with group I IV PH. Methods A prospective registry pre-capillary evaluated single tertiary center was used. Echocardiography were performed same day. Dedicated software for left ventricle used RV. global index (RVGWI) calculated as area From RVGWI, constructive (RVGCW; contributing shortening during systole lengthening isovolumic relaxation), wasted (RVGWW; efficiency (RVGWE; relation RVGCW RVGWW) estimated. Pearson’s correlation applied assess correlations continuous variables. Results 17 pts (80% women, mean age 67 ± 10 years) included. Conventional echocardiographic evaluation systolic function, such TAPSE, annular tricuspid s’ velocity fractional change (FAC), did correlate artery pressure (mPAP) vascular resistance (PVR). Strong found ventricle-pulmonary (RV-PA) coupling mPAP (r = -0,655, p 0,006) RVP(r - 0,610, 0,017), well GLS 0,749, 0,001 r 0,622, 0,01, respectively). Of indexes, RVGWW RVGWE strongly correlated PVR: increase, RVGWI -0,581, 0,015 -0,536, 0,027, respectively) -0,779, < -0,773, 0,001, decline significantly, whereas 0,735, 0,800, 0,001) increases. In our population, only didn’t significantly high afterload (r= −0,304, 0,235 mPAP, -0,181, 0,488 RVP). Conclusions New methods are crucial overload, since conventional do perform well. Novel assessment associated